San Jose, California

December 1, 2004

Caliper Life Sciences and PhyNexus Announce Complete Solution for Rapid, Automated Antibody Purification and Analysis

HOPKINTON, Mass. and SAN JOSE, Calif., November, 2004 -- Caliper Life Sciences, Inc. (Nasdaq: CALP), in collaboration with PhyNexus Inc, announced that it has integrated the PhyNexus® PhyTip™ column technology for protein purification and enrichment into the Caliper Sciclone ALH 3000 Liquid Handling Workstation, followed by rapid detection with the LabChip 90® electrophoresis system. In as little as 15 minutes, researchers can purify and enrich up to 96 engineered proteins or antibodies, and confirm purity and yield in about a minute per sample.

“We are excited to offer our customers new turn-key solutions that combine our leading expertise in liquid handling and LabChip technologies with the proprietary PhyNexus products that complement our focus on high throughput sample preparation for genomic and proteomic research,” commented Mark Roskey, Ph.D., Vice President of Marketing at Caliper Life Sciences. “The ability to couple automated high-throughput protein purification with rapid, high quality separation and analysis on the LabChip 90 system will truly enhance standardization and efficiencies of any protein research group or production facility.”

“By integrating the combined technologies available from Caliper and the novel high performance purification products from PhyNexus, our customers who are involved with antibody therapeutics will be able to cost-effectively increase their throughput capabilities and hence reduce the time to screen for potential antibodies that can be brought to trials,” said PhyNexus Executive Vice President of Business Development, Christopher Hanna, Ph.D.

About the Caliper Sciclone ALH 3000 Liquid Handling Workstation and LabChip 90 Electrophoresis System

The Caliper Sciclone ALH 3000 Liquid Handling Workstation offers leading-edge precision, adaptability, and scalability, and enables the automated processing of reagent samples for life science research and diagnostic testing. Leveraging a unique, open and modular design along with a wide range of interchangeable pipetting options and accessories, the Caliper Sciclone Liquid Handling Workstation can be configured to automate many applications, from nucleic acid and protein sample preparation protocols to molecular and cell-based screening assays, and more.

The LabChip 90 System offers complete protein and DNA analysis without the trouble of SDS-PAGE and agarose gels. The system samples directly from 96- and 384-well plates and automates the manual steps of slab gel electrophoresis onto a microfluidic chip. Quantitative sizing and concentration data are generated in just seconds per sample, and hundreds of samples can be processed in a few hours. This inexpensive alternative to gels is ideal for analysis of crude lysates, purified proteins, PCR products, restriction digests and more.

About PhyTip columns

PhyTip columns (Patents Pending) are unique proprietary devices designed to capture, purify and enrich antibodies and engineered proteins using affinity resins such as Protein A, Protein G, IMAC (Ni-NTA) and Glutathione. The process to purify(>95%purity) and enrich samples (up to 50x enrichment) in a micro volume format, can take less than 15 minutes and produces a fully functional protein for use in subsequent functional assays.

About Caliper Life Sciences

Caliper Life Sciences uses its advanced liquid handling and LabChip technologies to create leading-edge tools that accelerate drug discovery and enable diagnosis of disease. Caliper headquarters is located in Hopkinton, Massachusetts, with R&D, operations and manufacturing facilities for LabChip devices in Mountain View, California, and direct sales, service and applications support throughout the world. Caliper customers and partners include many of the largest pharmaceutical, biotechnology, and life sciences companies. For more information, please visit Caliper's web site at www.caliperLS.com.

About PhyNexus

PhyNexus has developed a unique technology to address the need for high performance, micro volume protein purification and enrichment with its PhyTip columns. These disposable devices can be used to rapidly prepare fully functional, purified recombinant proteins and antibodies with the highest performance. PhyNexus is headquartered in San Jose, California. Further information on PhyNexus can be found at www.phynexus.com.

LabChip and Caliper are registered trademarks of Caliper Life Sciences, Inc.

PhyNexus is a registered trademark of PhyNexus, Inc.

PhyTip is a trademark of PhyNexus, Inc.

PhyNexus Contact:

P J Schmit

Chief Operating Officer

408-267-7214